Not known Factual Statements About pkrrating
The interfacial residues are really conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a design wherever activating RNA serves for a scaffold to bind a number of PKR monomers, rising the near